De-escalation strategies in the oncological management of HPV-positive oropharyngeal cancer.

Hpv vaccine in cancer

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De-escalation strategies in the oncological management of HPV-positive oropharyngeal cancer. Source: ORL. Author s : Zahu, Renata; Sturzu, Daniela; Kacso, Gabriel; Ciuleanu, Elisabeta Abstract: HPV-positive oropharyngeal cancers have registered a rising incidence in the last two decades, especially among young nonsmoking adults. Retrospective studies have shown that the prognosis of these cancers is superior to the one of HPV-negative cancers.

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The combined treatment, such as radiochemotherapy or surgery followed by adjuvant radiotherapy, causes serious acute and late toxicities, like mucositis, dysphagia, xerostomia or cervical fibrosis. Given the young age group and the better prognosis of HPV-positive cancers, a series of hpv vaccine in cancer strategies to deintensify the treatment have been introduced, such as lower total dose of radiotherapy, omitting chemotherapy or replacing some cytotoxic agents with other less toxic agents.

Mayo Clinic Minute: HPV Vaccine Prevents Cancer

The present paper presents the standard treatment for HPV-positive cancers and a review of the published or still pending studies for de-escalation. We also list some common late toxicities with an impact on the quality of life.

The assessment of parental acceptance of HPV vaccine in a family medicine practice. English Abstract: Introduction.

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