Papilloma neoplasm. BiosciAbstracts
Nicolau Institute of Virology, Bucharest, Romania.
Introduction: The deregulation in miRNA expression has been described in thyroid tumors, and is considered an important factor in thyroid carcinogenesis. Objective: We aimed to detect miRNAs species differentially expressed between tumor and peritumoral tissue in papillary thyroid carcinoma. Materials and papilloma neoplasm After informed consent and study approval by ethics committee, 24 patients were included in the study: seven patients with classic papillary thyroid papilloma neoplasm cPTC14 patients with follicular variant of papillary thyroid carcinomas fvPTC and three patients with insular and sclerosing variant of PTC, using intra-operatively obtained tumor and peritumoral normal tissue.
Results: Our analysis showed that miRNA papilloma neoplasm papilloma neoplasm between normal and tumor tissues. Applying an asymptotic P value below 0. Conclusion: miRNA microarrays expression profile using a specific platform allowed a very good differentiation between tumor and normal thyroid tissue, providing an important tool for the individualized, specific variant-based management of thyroid cancer.